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Two independent reviewers read titles, abstracts, and full text papers and applied the inclusion criteria. Two reviewers independently extracted data from included full text papers. For each study, we extracted data on baseline characteristics (age, sex, histology, stage, grade, and smoking history) of the study population that could potentially confound the link between smoking and the outcome. We also extracted the number of continuing smokers, the number of quitters, and the length of follow up. We extracted survival outcomes as hazard ratios with 95% confidence intervals. In some studies, observed risk was presented as a proportion of expected risk calculated by Poisson regression modelling with general population data. In these cases, we calculated the hazard ratio by indirect comparison.14 We combined extracted hazard ratios by using a random effects inverse variance model in Stata. We compared adjusted and unadjusted estimates separately for each outcome in both non small cell and small cell lung cancer, and we tested for statistical heterogeneity by using the I2 test. Papers in languages other than English were translated.
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